看到文章 PLoS Genet. 2016 ，提到了 CpG island methylator phenotype (CIMP) subtype

Classification of the CIMP and non-CIMP subtypes 过程

Methylation datasets of 529 TCGA COADREAD samples were obtained from https://tcga-data.nci.nih.gov/tcga/. For the 2000 probes showing the highest variance in the TCGA samples, we made clustered heat maps of β values for only the TCGA samples.
如下：

无法理解的是，这两个组别颜色太接近，不知道作者为什么这样的配色方案选择。

两个重要基因集

主要是上面文献提到的两个参考文章 CpG island promoters of the epigenetic gatekeepers [14] and CIMP-related genes [39].