无意中看到了于2017年7月发表在cancer cell杂志的文章：《Common Molecular Subtypes Among Asian Hepatocellular Carcinoma and Cholangiocarcinoma》，是泰国人的癌症队列成果。
其链接是；https://www.cell.com/cancer-cell/pdf/S1535-6108(17)30205-2.pdf ，建议跟 Cell. 2017 Jun 15的文章对比看《Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma》
而且居然是多组学哦，而且涉及到了两种肝癌，Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) 。
We identified common molecular subtypes linked to similar prognosis among 199 Thai ICC and HCC patients through systems integration of genomics, transcriptomics, and metabolomics.
涉及到的泰国学术单位有：Laboratory of Chemical Carcinogenesis, Chulabhorn Research Institute, Bangkok 10210, Thailand Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand Chulabhorn Hospital, Bangkok 10210, Thailand Rajavej Hospital, Chiang Mai 50000, Thailand National Cancer Institute, Bangkok 10400, Thailand也算是开了个眼界，说不定很多年以后有粉丝就去东南亚发展，可以考虑一下泰国哦。我对泰国还是蛮有好感的，明年4月15附近的泼水节超级好玩，我去过曼谷和清迈，各有各的特色。
如下所示，可以看到Intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) 差异还是蛮大，然后每个肝癌又可以细分为不同的亚群：
这样的病人之间的异质性其实是老生常谈啦，目前都是单细胞水平的数据来看病人内部的不同细胞的异质性了。
其多组学数据，主要是：Affymetrix Array HTA2.0 (TIGER-LC) This Study GSE76297 Affymetrix Genome-Wide Human SNP Array 6.0 (TIGER-LC) This Study GSE76213 LCI Cohort-Microarray (Roessler et al., 2010) GSE14520 (https://www.ncbi.nlm.nih.gov/geo/query/acc. cgi?acc=gse14520) ICC Microarray (Andersen et al., 2012; Nakamura et al., 2015) GSE26566 (https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE26566) TCGA Data TCGA (https://portal.gdc.cancer.gov) TCGA-LIHC文末友情推荐
