找到的peaks需要过滤掉ENCODE的黑名单区域

表观组学流程,主要看到就是分析拿到peaks区域,包括ChIP-seq,ATAC-seq,甚至单细胞的ATAC-seq。
但是拿到了peaks后,还有一个非常重要的步骤, 就是需要过滤掉ENCODE的黑名单区域。
比如,我看到文章:《Chromatin Potential Identified by Shared Single-Cell Profiling of RNA and Chromatin》,链接是:https://doi.org/10.1016/j.cell.2020.09.056 就提到了:peaks overlapping with ENCODE blacklisted regions (https://sites.google.com/site/anshulkundaje/projects/blacklists) were filtered out.
是如下所示的bed文件,里面涵盖的坐标区域的peaks都是可以直接被过滤掉。

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