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单细胞转录组看头颈癌的原位癌和复发癌区别

单细胞转录组探索头颈癌症的转移癌和原位癌区别

文章发表于2017年12月,在CELL杂志:Single-Cell Transcriptomic Analysis of Primary and Metastatic Tumor Ecosystems in Head and Neck Cancer 测序如下;

We profiled transcriptomes of ∼6,000 single cells from 18 head and neck squamous cell carcinoma (HNSCC) patients, including five matched pairs of primary tumors and lymph node metastases.

同时也对这些病人测了whole-exome sequencing (WES) and targeted genotyping (SNaPshot) data,但是这些数据公布在 phs001474.v1.p1 ,不是很方便下载。 Continue reading

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时间序列单细胞转录组数据分析

时间序列单细胞转录组数据分析

文章是: Reconstruction of developmental landscapes by optimal-transport analysis of single-cell gene expression sheds light on cellular reprogramming. 虽然于2017年9月公布在了bioRxiv上面,但是至今仍然没正式发表,包含了六万多个单细胞转录组数据,持续追踪了MEF细胞系诱导为IPSC细胞的动态变化过程,并且从发育的角度分析了这些数据

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